Molecular Mechanisms of Muscle Glucose Uptake in Response to Resistance Exercise: A Review

Santos JL, Araujo SS, Estevam CS, Lima CA, Carvalho CRO, Lima FB, Marcal AC. Molecular Mechanisms of Muscle Glucose Uptake in Response to Resistance Exercise: A Review. JEPonline 2017;20(4):200-211. Evidence shows that physical exercise carried out systematically promotes numerous health benefits, i...

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Published in:Journal of exercise physiology online 2017-08, Vol.20 (4), p.200
Main Authors: Lopes dos Santos, Jymmys, Silva de Araujo, Silvan, dos Santos Estevam, Charles, Lima, Clesio Andrade, de Oliveira Carvalho, Carla Roberta, Lima, Fabio Bessa, Carlos Margal, Anderson
Format: Article
Language:English
Subjects:
Exercise
Exercise physiology
Glucose
Glucose metabolism
Insulin
Isometric exercise
Metabolism
Metabolomics
Muscles
Physical fitness
Physiological aspects
Physiological research
Strength training
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Summary:Santos JL, Araujo SS, Estevam CS, Lima CA, Carvalho CRO, Lima FB, Marcal AC. Molecular Mechanisms of Muscle Glucose Uptake in Response to Resistance Exercise: A Review. JEPonline 2017;20(4):200-211. Evidence shows that physical exercise carried out systematically promotes numerous health benefits, including improvements in glucose homeostasis. Of all types of physical activity, resistance training is effective in promoting increased strength, speed, power, hypertrophy, and metabolic effects such as increased insulin sensitivity and control in glycogen metabolism. Since there are still gaps requiring attention in regards to the molecular mechanisms leading to effective insulin signaling, this paper attempts to review the effects and implications of resistance exercise on the major intracellular protein activities. In this regard, we set out to understand the role of resistance training on IRS1, IRS2, PI3K, Akt/PKB, and GLUT4 activity, which can lead to the development of possible future interventions to improve physical performance and mitigate the effects of altered metabolic conditions such as obesity, insulin resistance, and type 2 diabetes mellitus. Key Words: Insulin Resistance, Insulin Signaling, Intracellular proteins, Resistance Exercise
ISSN:1097-9751
1097-9751