C18-Free Organic–Inorganic Hybrid Silica Particles Derived from Sole Silsesquioxane for Reversed-Phase HPLC

Ethyl-bridged organic–inorganic hybrid silica particles were prepared via a sol–gel and hydrothermal synthesis approach using 1,2-bis(triethoxysilyl)ethane (BTESE) as the sole precursor, and triblock copolymer poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (P123) and dod...

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Bibliographic Details
Published in:Chromatographia 2018-02, Vol.81 (2), p.247-256
Main Authors: Peng, Shi-Hao, Yue, Xiu-Yun, Wang, Ya-Li, Wei, Qi, Cui, Su-Ping, Nie, Zuo-Ren, Li, Qun-Yan
Format: Article
Language:English
Subjects:
Analytical Chemistry
Block copolymers
Chemical bonds
Chemistry
Chemistry and Materials Science
Chromatography
Dodecyltrimethylammonium bromide
Esters
Ethane
Ethylbenzene
Ethylene oxide
High performance liquid chromatography
Laboratory Medicine
Original
Pharmacy
Pore size
Porosity
Propylene
Propylene oxide
Proteomics
Silica
Silicon dioxide
Sol-gel processes
Stability
Uracil
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Summary:Ethyl-bridged organic–inorganic hybrid silica particles were prepared via a sol–gel and hydrothermal synthesis approach using 1,2-bis(triethoxysilyl)ethane (BTESE) as the sole precursor, and triblock copolymer poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (P123) and dodecyltrimethylammonium bromide (DTAB) as combined templates. The morphology, pore structure, chemical composition and liquid chromatographic performance of the obtained materials were investigated in detail. The particles exhibit a high surface area of 1136.40 m 2 /g, together with a pore volume of 0.39 cm 3 /g and an average pore size of 2.30 nm. Used as stationary phase for high-performance liquid chromatography (HPLC), the particles without extra bonding either C 18 or C 8 can successfully separate a mixture of uracil, phenol, pyridine, methylbenzene, ethylbenzene and tert-butylbenzene. The obtained materials also show practical application in the separation of phthalate acid esters (PAEs), which are harmful to environment and human health. Although the columns packed with ethyl-bridged organic–inorganic hybrid silica show lower column efficiency and peak symmetry compared to commercial column, they have considerably higher chemical stability in alkaline mobile phase. The HSS column also possesses high mechanical stability which is similar to that of the commercial column.
ISSN:0009-5893
1612-1112
DOI:10.1007/s10337-017-3428-6