Biomarker responses of Peromyscus leucopus exposed to lead and cadmium in the Southeast Missouri Lead Mining District

Biomarker responses and histopathological lesions have been documented in laboratory mammals exposed to elevated concentrations of lead and cadmium. The exposure of white-footed mice ( Peromyscus leucopus ) to these metals and the potential associated toxic effects were examined at three contaminate...

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Bibliographic Details
Published in:Environmental monitoring and assessment 2018-02, Vol.190 (2), p.104-16, Article 104
Main Authors: Beyer, W. Nelson, Casteel, Stan W., Friedrichs, Kristen R., Gramlich, Eric, Houseright, Ruth A., Nichols, John R., Karouna-Renier, Natalie K., Kim, Dae Young, Rangen, Kathleen L., Rattner, Barnett A., Schultz, Sandra L.
Format: Article
Language:English
Subjects:
Acidic soils
Alkaline soils
Aminolevulinic acid
Animal models
Animals
Atmospheric Protection/Air Quality Control/Air Pollution
Bioaccumulation
Biological magnification
Biomarkers
Biomarkers - metabolism
Blood
Cadmium
Cadmium - analysis
Cadmium - metabolism
Cadmium - toxicity
Dehydration
Deoxyribonucleic acid
DNA
DNA damage
Earth and Environmental Science
Ecology
Ecotoxicology
Environment
Environmental Management
Environmental Monitoring
Environmental science
Erythrocytes
Exposure
Glutathione
Heavy metals
Kidneys
Laboratories
Lead
Lead - analysis
Lead - metabolism
Lead - toxicity
Lesions
Lipid peroxidation
Liver
Liver - chemistry
Mice
Mine wastes
Mining
Missouri
Monitoring/Environmental Analysis
Oxidative stress
Peromyscus
Peromyscus - physiology
Peromyscus leucopus
Peroxidation
Porphobilinogen Synthase
Regression analysis
Regression models
Risk assessment
Rodents
Soil contamination
Soils
Thiols
Toxicity
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Summary:Biomarker responses and histopathological lesions have been documented in laboratory mammals exposed to elevated concentrations of lead and cadmium. The exposure of white-footed mice ( Peromyscus leucopus ) to these metals and the potential associated toxic effects were examined at three contaminated sites in the Southeast Missouri Lead Mining District and at a reference site in MO, USA. Mice from the contaminated sites showed evidence of oxidative stress and reduced activity of red blood cell δ-aminolevulinic acid dehydratase (ALAD). Histological examinations of the liver and kidney, cytologic examination of blood smears, and biomarkers of lipid peroxidation and DNA damage failed to show indications of toxic effects from lead. The biomagnification factor of cadmium (hepatic concentration/soil concentration) at a site with a strongly acid soil was 44 times the average of the biomagnification factors at two sites with slightly alkaline soils. The elevated concentrations of cadmium in the mice did not cause observable toxicity, but were associated with about a 50% decrease in expected tissue lead concentrations and greater ALAD activity compared to the activity at the reference site. Lead was associated with a decrease in concentrations of hepatic glutathione and thiols, whereas cadmium was associated with an increase. In addition, to support risk assessment efforts, we developed linear regression models relating both tissue lead dosages (based on a previously published a laboratory study) and tissue lead concentrations in Peromyscus to soil lead concentrations.
ISSN:0167-6369
1573-2959
DOI:10.1007/s10661-017-6442-0