Glutathione peroxidase deficiency and childhood seizures

4 children with intractable seizures, repeated infections, and intolerance to anticonvulsants had evidence of glutathione peroxidase deficiency. 2 had low intracellular enzyme activity but normal blood selenium and high plasma glutathione peroxidase concentrations. The other 2 had low intracellular...

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Bibliographic Details
Published in:The Lancet (British edition) 1991-06, Vol.337 (8755), p.1443-1444
Main Authors: Weber, G.F., Maertens, P., Meng, X., Pippenger, C.E.
Format: Article
Language:English
Subjects:
Anticonvulsants - adverse effects
Children & youth
Drugs
Glutathione Peroxidase - blood
Glutathione Peroxidase - deficiency
Glutathione Reductase - deficiency
Humans
Infant
Intracellular Fluid - enzymology
Male
Medical disorders
Medical research
Recurrence
Seizures - drug therapy
Seizures - enzymology
Selenium - blood
Selenium - therapeutic use
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Description
Summary:4 children with intractable seizures, repeated infections, and intolerance to anticonvulsants had evidence of glutathione peroxidase deficiency. 2 had low intracellular enzyme activity but normal blood selenium and high plasma glutathione peroxidase concentrations. The other 2 had low intracellular glutathione peroxidase activity with low circulating glutathione peroxidase and selenium concentrations. The clinical state of the children improved after discontinuation of anticonvulsant medication and selenium substitution.
ISSN:0140-6736
1474-547X
DOI:10.1016/0140-6736(91)93130-2