Lipid profiles in untreated severe congenital isolated growth hormone deficiency through the lifespan

Summary objective Growth hormone deficiency (GHD) is associated with adverse changes in lipid profile. However, changes in lipids through life in a homogeneous group of GHD subjects have not been defined. patients and measurements We examined lipid levels in a group of untreated severely GHD patient...

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Bibliographic Details
Published in:Clinical endocrinology (Oxford) 2002-07, Vol.57 (1), p.89-95
Main Authors: Gleeson, Helena K., Souza, Anita H. O., Gill, Matthew S., Wieringa, Gilbert E., De A. Barretto, Elenilde S., Barretto‐Filho, J. A. S., Shalet, Stephen M., Aguiar‐Oliveira, Manuel H., Clayton, Peter E.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Brazil
Case-Control Studies
Child
Child, Preschool
Cholesterol - blood
Cholesterol, HDL - blood
Disease Progression
Endocrinopathies
Female
Growth Hormone - deficiency
Humans
Hypothalamus. Hypophysis. Epiphysis (diseases)
Lipids - blood
Male
Medical sciences
Middle Aged
Mutation
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Pituitary Diseases - blood
Pituitary Diseases - genetics
Receptors, Somatotropin - genetics
Statistics, Nonparametric
Triglycerides - blood
Tropical medicine
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Summary:Summary objective Growth hormone deficiency (GHD) is associated with adverse changes in lipid profile. However, changes in lipids through life in a homogeneous group of GHD subjects have not been defined. patients and measurements We examined lipid levels in a group of untreated severely GHD patients with a mutation in the GHRH receptor gene from a rural community in North‐east Brazil. Lipid profiles in 15 GHD subjects [eight children and adolescents (one male), age (median [range]) 13·2 (5·4–19·9) years; seven adults (one male), age 47 (33–66) years] were compared with those in 29 indigenous controls from the same extended kindred [17 children and adolescents (six male), age 10·2 (5·3–18·4) years; 12 adults (eight male), age 54·5 (33–80) years]. All GHD subjects had a peak GH response of < 0·5 ng/ml in response to an insulin tolerance test and extremely reduced IGF‐1 levels (median 5·5 ng/ml). Data were compared between cohorts and with an age‐ and sex‐matched white American reference population. results Abnormalities were confined to plasma total cholesterol (TC) and low‐density lipoprotein cholesterol (LDL‐C) levels. More GHD children had levels of plasma TC and LDL‐C above the 95th percentile for our reference population (3/8 and 4/7, respectively) compared to controls (0/17 and 1/15, respectively) (P 
ISSN:0300-0664
1365-2265
DOI:10.1046/j.1365-2265.2002.01568.x