FABSIM: a software for generating F ST distributions with various ascertainment biases

We have developed a software that applies ascertainment bias on simulated DNA sequences and calculates F ST on them, so they can be used to generate neutral distributions that are appropriate to test whether the genetic differentiation of a particular gene between populations is compatible with neut...

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Bibliographic Details
Published in:Bioinformatics 2008-12, Vol.24 (23), p.2790-2791
Main Authors: Ramírez-Soriano, Anna, Calafell, Francesc
Format: Article
Language:English
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Summary:We have developed a software that applies ascertainment bias on simulated DNA sequences and calculates F ST on them, so they can be used to generate neutral distributions that are appropriate to test whether the genetic differentiation of a particular gene between populations is compatible with neutral evolution, or, on the contrary, suggests local adaptation by natural selection. Availability: FABSIM is available from http://www.snpator.com/public/downloads/aRamirez/FABSIM/. Contact: francesc.calafell@upf.edu. Supplementary information: Supplementary data are available at Bioinformatics online. The data from which figures are built can be dowloaded from http://www.snpator.com/public/downloads/aRamirez/.
ISSN:1367-4803
1460-2059
1367-4811
DOI:10.1093/bioinformatics/btn531