Study of the prophylactic effect of droperidol, alizapride, propofol and promethazine on spinal morphine-induced pruritus

We have compared the use of alizapride, propofol, droperidol and promethazine for the prevention of spinal morphine-induced pruritus. Three hundred ASA I or II women undergoing Caesarean section under spinal anaesthesia, in which morphine 0.2 mg was added to a local anaesthetic, were assigned random...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 2006-06, Vol.96 (6), p.796-800
Main Authors: Horta, M.L., Morejon, L.C.L., da Cruz, A.W., dos Santos, G.R., Welling, L.C., Terhorst, L., Costa, R.C., Alam, R.U.Z.
Format: Article
Language:English
Subjects:
Adolescent
Adult
alizapride
anaesthetics i.v
anaesthetics i.v., propofol
analgesics opioid
analgesics opioid, morphine
Analgesics, Opioid - adverse effects
Anesthesia
Anesthesia, Obstetrical - adverse effects
Anesthesia, Spinal - adverse effects
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
antihistamines
antihistamines, promethazine
Antipruritics - therapeutic use
Biological and medical sciences
Cesarean Section
complications
complications, pruritus
Double-Blind Method
droperidol
Droperidol - therapeutic use
Drug Eruptions - prevention & control
Female
Humans
hypnotics butyrophenone
hypnotics butyrophenone, droperidol
Medical sciences
Middle Aged
morphine
Morphine - adverse effects
pharmacology
pharmacology, alizapride
Pregnancy
promethazine
Promethazine - therapeutic use
propofol
Propofol - therapeutic use
pruritus
Pruritus - chemically induced
Pruritus - prevention & control
Pyrrolidines - therapeutic use
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Summary:We have compared the use of alizapride, propofol, droperidol and promethazine for the prevention of spinal morphine-induced pruritus. Three hundred ASA I or II women undergoing Caesarean section under spinal anaesthesia, in which morphine 0.2 mg was added to a local anaesthetic, were assigned randomly to receive i.v., in the operating room, just after delivery of the baby, alizapride 100 mg, propofol 20 mg, droperidol 1.25 mg, promethazine 50 mg or saline 2 ml (control group). In the postoperative period, the women were assessed for pruritus (absent, mild, moderate or severe) or other untoward symptoms by blinded observers. We used 95% confidence limits (95% CI) for the cumulative incidence of moderate and severe pruritus to compare the groups, and the NNT and 95% CI to compare droperidol, propofol and alizapride as for their effectiveness in preventing pruritus. For other untoward effects, the χ2-test was used, results being considered significant when P
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/ael072