Three‐Component Thieno[2,3‐b]indole Synthesis from Indoles, Alkenes or Alkynes and Sulfur Powder under Metal‐Free Conditions

A Bronsted acid promoted three‐component synthesis of substituted thieno[2,3‐b]indole has been developed starting from indoles, alkenes or alkynes, and sulfur powder. N,N‐Dimethylformamide plays an important role to convert the starting materials into the fused products. Various functional groups at...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2017-12, Vol.359 (24), p.4300-4304
Main Authors: Li, Bin, Ni, Penghui, Huang, Huawen, Xiao, Fuhong, Deng, Guo‐Jun
Format: Article
Language:English
Subjects:
Alkenes
Alkynes
C−H functionalization
Functional groups
Indoles
Metal-free
Substrates
Sulfur
Sulfur powder
Synthesis
Thieno[2,3-b]indole
Three-component reaction
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Summary:A Bronsted acid promoted three‐component synthesis of substituted thieno[2,3‐b]indole has been developed starting from indoles, alkenes or alkynes, and sulfur powder. N,N‐Dimethylformamide plays an important role to convert the starting materials into the fused products. Various functional groups attached to substrates were well tolerated to afford the corresponding products in moderate to good yields under very simple reaction conditions.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201701106