Recovery from propofol anaesthesia supplemented with remifentanil

We have examined the effects on recovery end-points of supplementation of a propofol-based anaesthetic with remifentanil. After induction of anaesthesia with propofol and remifentanil 1.0 μg kg−1, 15 patients each were randomly allocated to target plasma propofol concentrations of 2, 3, 4 or 5 μg ml...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 2001-03, Vol.86 (3), p.361-365
Main Authors: O'Hare, R.A., Mirakhur, R.K., Reid, J.E., Breslin, D.S., Hayes, A
Format: Article
Language:English
Subjects:
Adolescent
Adult
anaesthesia i.v
analgesics opioid, remifentanil
Analgesics, Opioid - pharmacology
Anesthesia
Anesthesia Recovery Period
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anesthetics, Intravenous - administration & dosage
Anesthetics, Intravenous - blood
Anesthetics, Intravenous - pharmacology
Biological and medical sciences
Consciousness - drug effects
Dose-Response Relationship, Drug
Drug Interactions
General anesthesia. Technics. Complications. Neuromuscular blocking. Premedication. Surgical preparation. Sedation
Humans
Medical sciences
Middle Aged
pharmacodynamics
Piperidines - pharmacology
propofol
Propofol - administration & dosage
Propofol - blood
Propofol - pharmacology
Psychometrics
Remifentanil
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Summary:We have examined the effects on recovery end-points of supplementation of a propofol-based anaesthetic with remifentanil. After induction of anaesthesia with propofol and remifentanil 1.0 μg kg−1, 15 patients each were randomly allocated to target plasma propofol concentrations of 2, 3, 4 or 5 μg ml−1for maintenance of anaesthesia. Remifentanil was administered by infusion for supplementation in doses required for maintenance of adequate anaesthesia. All patients received 50% nitrous oxide in oxygen and ventilation was controlled. The total amount of drugs used and times to different recovery end-points were recorded. Cognitive function was also assessed using a Mini-Mental State questionnaire. The median dose of remifentanil for maintenance of adequate anaesthesia (excluding the initial bolus dose) in the four groups was 0.21, 0.15, 0.11 and 0.13 μg kg−1 min−1 respectively (P=0.0026). The median times to eye opening and orientation were shortest in the 2 μg ml−1 group [6.0 and 6.5 min, 8.5 and 10.8 min, 13.4 and 15.8 min, and 14.2 and 19.5 min respectively in the propofol 2, 3, 4, and 5 μg ml−1 groups respectively (P
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/86.3.361