Pregabalin and dexamethasone for postoperative pain control: a randomized controlled study in hip arthroplasty

Optimal pain treatment with minimal side-effects is essential for early mobility and recovery in patients undergoing total hip arthroplasty. We investigated the analgesic effect of pregabalin and dexamethasone in this surgical procedure. One hundred and twenty patients were randomly allocated to eit...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 2008-10, Vol.101 (4), p.535-541
Main Authors: Mathiesen, O., Jacobsen, L.S., Holm, H.E., Randall, S., Adamiec-Malmstroem, L., Graungaard, B.K., Holst, P.E., Hilsted, K.L., Dahl, J.B.
Format: Article
Language:English
Subjects:
Aged
analgesia
analgesia, postoperative
Analgesics, Non-Narcotic - therapeutic use
Analgesics, Opioid - administration & dosage
Analgesics, Opioid - adverse effects
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Arthroplasty, Replacement, Hip
Biological and medical sciences
Consciousness - drug effects
Dexamethasone - therapeutic use
Double-Blind Method
Drug Administration Schedule
Drug Therapy, Combination
Female
gamma-Aminobutyric Acid - analogs & derivatives
gamma-Aminobutyric Acid - therapeutic use
Humans
Male
Medical sciences
Middle Aged
Morphine - administration & dosage
Morphine - adverse effects
pain
Pain Measurement - methods
pain, postoperative
Pain, Postoperative - prevention & control
postoperative
Postoperative Nausea and Vomiting - chemically induced
Postoperative Nausea and Vomiting - prevention & control
Pregabalin
Prospective Studies
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Summary:Optimal pain treatment with minimal side-effects is essential for early mobility and recovery in patients undergoing total hip arthroplasty. We investigated the analgesic effect of pregabalin and dexamethasone in this surgical procedure. One hundred and twenty patients were randomly allocated to either Group A (placebo), Group B (pregabalin 300 mg), or Group C (pregabalin 300 mg+dexamethasone 8 mg). The medication and acetaminophen 1 g were given before operation. Spinal anaesthesia was performed. Postoperative pain treatment was with acetaminophen 1 g three times daily and patient-controlled i.v morphine, 2.5 mg bolus. Nausea was treated with ondansetron. Morphine consumption, pain intensity at rest and during mobilization, nausea and vomiting, sedation, dizziness, and consumption of ondansetron were recorded 2, 4, and 24 h after operation. P
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/aen215