Transgenerational genomic instability in the first generation offspring of mice exposed to low-intensity red and near-infrared irradiation in vivo

Transgenerational genomic instability in the first generation offspring of mice exposed to lowintensity infrared laser (632.8 nm) and light-emitting-diode infrared irradiation (850 nm) was investigated in vivo. It was found that the level of spontaneous damage in bone marrow according to the micronu...

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Bibliographic Details
Published in:Biophysics (Oxford) 2017-09, Vol.62 (5), p.836-841
Main Authors: Zaichkina, S. I., Dyukina, A. R., Rozanova, O. M., Romanchenko, S. P., Simonova, N. B., Sorokina, S. S., Yusupov, V. I., Bagratashvili, V. N.
Format: Article
Language:English
Subjects:
Adaptive radiation
Biological and Medical Physics
Biophysics
Biophysics of Complex Systems
Bone marrow
Exposure
Genomic instability
Growth rate
I.R. radiation
Infrared lasers
Infrared radiation
Irradiation
Mice
Offspring
Organs
Physics
Physics and Astronomy
Radiation
Radiosensitivity
Reactive oxygen species
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Summary:Transgenerational genomic instability in the first generation offspring of mice exposed to lowintensity infrared laser (632.8 nm) and light-emitting-diode infrared irradiation (850 nm) was investigated in vivo. It was found that the level of spontaneous damage in bone marrow according to the micronucleus test, the level of reactive oxygen species in whole blood, and the mass index of lymphoid organs in all of the descendants of irradiated mice did not increase. After additional X-ray exposure of the progeny at a dose rate of 1.5 Gy, a decrease in the level of damage and the absence of an adaptive response were revealed upon testing according to “radiosensitivity” and the radiation-induced adaptive-response scheme (0.1 + 1.5 Gy), respectively, compared to the descendants of nonirradiated mice. The rate of tumor growth in the offspring of irradiated mice did not differ from that in the descendants of nonirradiated mice, although inhibition of the tumor growth rate was observed in their irradiated parents. The survival rate after irradiation at a dose rate of 6.5 Gy did not differ from both the parents and the control.
ISSN:0006-3509
1555-6654
DOI:10.1134/S0006350917050244