Cumulative evidence for relationships between multiple variants in the VTI1A and TCF7L2 genes and cancer incidence

Genetic studies have linked the VTI1A‐TCF7L2 region with risk of multiple cancers. However, findings from these studies were generally inconclusive. We aimed to provide a synopsis of current understanding of associations between variants in the VTI1A‐TCF7L2 region and cancer susceptibility. We condu...

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Bibliographic Details
Published in:International journal of cancer 2018-02, Vol.142 (3), p.498-513
Main Authors: Zhang, Min, Tang, Mingshuang, Fang, Yanfei, Cui, Huijie, Chen, Siyu, Li, Junlong, Xiong, Hongyan, Lu, Jiachun, Gu, Dongqing, Zhang, Ben
Format: Article
Language:English
Subjects:
Brain tumors
Breast cancer
Cancer
Case-Control Studies
Chromosome 10
Colorectal cancer
Colorectal carcinoma
Data processing
Deoxyribonucleic acid
DNA
Encyclopedias
Genetic diversity
Genetic Predisposition to Disease
Genetic variance
genetic variant
Glioma
Health risks
Humans
Incidence
Lung cancer
Medical research
Molecular modelling
Neoplasms - epidemiology
Neoplasms - genetics
Pathogenesis
Qb-SNARE Proteins - genetics
Studies
susceptibility
TCF7L2
Transcription Factor 7-Like 2 Protein - genetics
VTI1A
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Summary:Genetic studies have linked the VTI1A‐TCF7L2 region with risk of multiple cancers. However, findings from these studies were generally inconclusive. We aimed to provide a synopsis of current understanding of associations between variants in the VTI1A‐TCF7L2 region and cancer susceptibility. We conducted a comprehensive research synopsis and meta‐analysis to evaluate associations between 17 variants in this region and risk of seven cancers using data from 32 eligible articles totaling 224,656 cancer cases and 324,845 controls. We graded cumulative evidence of significant associations using Venice criteria and false‐positive report probability tests. We also conducted analyses to evaluate potential function of these variants using data from the Encyclopedia of DNA Elements (ENCODE) Project. Eight variants showed a nominally significant association with risk of individual cancer (p 
ISSN:0020-7136
1097-0215
DOI:10.1002/ijc.31074