Apo-8'-Lycopenal and Apo-12'-Lycopenal Are Metabolic Products of Lycopene in Rat Liver1,2

The health benefits of lycopene as an anticarcinogenic compound have been widely studied but little is known about the metabolic products of lycopene produced in vivo. We investigated lycopene metabolites in the liver of F344 male rats that had been prefed a lycopene-containing diet (0.25 g lycopene...

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Bibliographic Details
Published in:The Journal of nutrition 2006-06, Vol.136 (6), p.1552
Main Authors: Gajic, Marija, Zaripheh, Susan, Sun, Furong, Erdman, John W
Format: Article
Language:English
Subjects:
Antioxidants
Liver
Metabolism
Rodents
Online Access:Get full text
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Summary:The health benefits of lycopene as an anticarcinogenic compound have been widely studied but little is known about the metabolic products of lycopene produced in vivo. We investigated lycopene metabolites in the liver of F344 male rats that had been prefed a lycopene-containing diet (0.25 g lycopene/kg diet). After 30 d of feeding, they were given a single oral dose of ^sup 14^C-labeled lycopene (421.8 kBq). The metabolic products of both nonradioactive and ^sup 14^C-labeled lycopene in rat liver were extracted and separated using HPLC and analyzed by UV/VIS spectrometry, online radioactive detection, and off-line and in-line positive ion electrospray ionization MS. Among a number of metabolite products formed, we identified apo-8';-lycopenal (λ^sub max^ = 473 nm and m/z = 417). The putative compound, apo-12'-lycopenal, was detected but no apo-10'-lycopenal was present. A number of other very polar, short-chain and/ or short chromophore compounds with UV/VIS absorption
ISSN:0022-3166
1541-6100