Detonation nanodiamonds as antioxidants in various test systems

Detonation nanodiamonds (DND) are shown to exhibit antioxidant activity both in vitro and in vivo. DNDs, when introduced into laboratory animals by oral delivery, decrease protein peroxidation in erythrocytes, inhibit peroxidation of lipids and proteins in blood plasma. In case a pro-oxidant, NaNO2,...

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Bibliographic Details
Published in:Journal of superhard materials 2017-09, Vol.39 (5), p.326-335
Main Authors: Shugalei, I. V., Borovikova, A. S., Voznyakovskii, A. P., Ilyushin, M. A.
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Blood plasma
Chemistry
Chemistry and Materials Science
Detonation
Diamonds
Erythrocytes
In vivo methods and tests
Laboratory animals
Lipids
Nanostructure
Physical Chemistry
Production
Properties
Proteins
Structure
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Summary:Detonation nanodiamonds (DND) are shown to exhibit antioxidant activity both in vitro and in vivo. DNDs, when introduced into laboratory animals by oral delivery, decrease protein peroxidation in erythrocytes, inhibit peroxidation of lipids and proteins in blood plasma. In case a pro-oxidant, NaNO2, is administered to animals, DND also protects them against the chemically induced oxidative stress. The results of the testing provide the experimental basis for recommending DND as a potential antioxidant for correcting oxidative damage of different origin.
ISSN:1063-4576
1934-9408
DOI:10.3103/S1063457617050045