Influence of hydration and crosslinking in transdermal delivery of nicotine from chitosan-based gels by thermal analysis

Chitosan is a biopolymer that forms hydrogels after swell in acid medium. The environment of the three-dimensional network of the chitosan-based hydrogels can be modified by its degree of swelling and crosslinking. In this way, nicotine was incorporated in the hydrogel formulations, with or without...

Full description

Saved in:
Bibliographic Details
Published in:Journal of thermal analysis and calorimetry 2017-12, Vol.130 (3), p.1455-1461
Main Authors: Lino, Monica E. S., Ruela, André L. M., Trevisan, Marcello G., Pereira, Gislaine R.
Format: Article
Language:English
Subjects:
Analysis
Analytical Chemistry
Biopolymers
Chemistry
Chemistry and Materials Science
Chitosan
Crosslinking
Drug delivery systems
Flux
Formulations
Gels
Glutaraldehyde
Hydrogels
Inorganic Chemistry
Measurement Science and Instrumentation
Nicotine
Physical Chemistry
Polymer crosslinking
Polymer Sciences
Stability analysis
Swelling
Thermal analysis
Transdermal drug delivery systems
Transdermal medication
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chitosan is a biopolymer that forms hydrogels after swell in acid medium. The environment of the three-dimensional network of the chitosan-based hydrogels can be modified by its degree of swelling and crosslinking. In this way, nicotine was incorporated in the hydrogel formulations, with or without crosslinking with glutaraldehyde (0.01%), in different swollen states. Transdermal delivery of nicotine by chitosan-based hydrogels was studied in order to achieve the prolonged administration of the drug. Thermal analysis indicated a preliminary stability of these formulations, and the mechanism of drug release from hydrogels was dependent of the swelling degree and crosslinking. These formulations were able to control the transdermal flux of nicotine for up to 48 h following zero-order kinetics. The hydrogels with higher amounts of water or the partially dried crosslinked hydrogels reduced the partition of nicotine into the skin, leading to a minor transdermal flux of the drug (
ISSN:1388-6150
1588-2926
DOI:10.1007/s10973-017-6129-3