Low transition temperature mixtures prompted one-pot synthesis of 5, 10 dihydropyrimido[4,5-b]quinoline-2,4(1H,3H)-dione derivatives

An efficient green protocol has been investigated for the synthesis of pyrimido[4,5-b]quinolines derivatives via one-pot three-component condensation of 4-chloro aniline, aromatic aldehyde and barbituric acid using low transition temperature mixtures as new generation and sustainable solvents. The p...

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Bibliographic Details
Published in:Research on chemical intermediates 2017-12, Vol.43 (12), p.7013-7028
Main Authors: Mohire, Priyanka P., Patil, Reshma B., Chandam, Dattatraya R., Jadhav, Sunetra J., Patravale, Ajinkya A., Kumbhar, Digambar R., Ghosh, Jai S., Deshmukh, Madhukar B.
Format: Article
Language:English
Subjects:
Aniline
Catalysis
Chemistry
Chemistry and Materials Science
Combinatorial analysis
Derivatives
Inorganic Chemistry
Organic compounds
Physical Chemistry
Quinoline
Scaffolds
Synthesis
Transition temperature
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Summary:An efficient green protocol has been investigated for the synthesis of pyrimido[4,5-b]quinolines derivatives via one-pot three-component condensation of 4-chloro aniline, aromatic aldehyde and barbituric acid using low transition temperature mixtures as new generation and sustainable solvents. The process was accomplished with the use of greener and recyclable reaction media, simple methodology, easy workup procedures and no chromatographic purification with high yield. This new approach is expected to discover some significance in combinatorial synthesis of biologically active scaffolds. Graphical Abstract
ISSN:0922-6168
1568-5675
DOI:10.1007/s11164-017-3033-1