Original Article: No association between the -399 C>T polymorphism of the neuropeptide Y gene and schizophrenia, unipolar depression or panic disorder in a Danish population

A polymorphism in the promoter region of the NPY gene at position -399 C>T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associa...

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Bibliographic Details
Published in:Acta psychiatrica Scandinavica 2006-01, Vol.113 (1), p.54
Main Authors: Lindberg, C, Koefoed, P, Hansen, E S, Bolwig, T G, Rehfeld, J F, Mellerup, E, Jørgensen, O S, Kessing, L V, Werge, T, Haugbøl, S, Wang, A G, Woldbye, D P D
Format: Article
Language:English
Subjects:
Genes
Mental depression
Panic attacks
Polymorphism
Schizophrenia
Online Access:Get full text
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Summary:A polymorphism in the promoter region of the NPY gene at position -399 C>T was recently reported to be associated with schizophrenia in a Japanese population and with treatment refractory unipolar depression in a Swedish population. The objective of this study was to investigate potential associations between the polymorphism and three psychiatric disorders in a Danish population. We investigated the occurrence of the polymorphism in patients with schizophrenia (n = 291), unipolar depression (n = 256) and panic disorder (n = 142) compared with controls (n = 716). We detected the polymorphism -399 C>T at a frequency of 48% in controls. No significant differences were found between genotype or allele frequencies in controls vs. the patient groups. The lack of association between the -399 C>T polymorphism and schizophrenia, unipolar depression or panic disorder, respectively, suggests that the polymorphism is not involved in the etiology of these disorders in the Danish population. [PUBLICATION ABSTRACT]
ISSN:0001-690X
1600-0447
DOI:10.1111/j.1600-0447.2005.00648.x