Preparation, characterization, antimicrobial and anticancer activities of Schiff base mixed ligand complexes

A new Schiff base ligand (HL) derived from quinoline-2-carboxaldehyde with 2-aminophenol (1:1 molar ratio) and its mixed ligand complexes, viz. 2,2′-bipyridine (1:1:1 molar ratio), have been synthesized and characterized by elemental analysis, spectroscopic studies, X-ray diffraction, ESR, magnetic...

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Bibliographic Details
Published in:Journal of thermal analysis and calorimetry 2017-11, Vol.130 (2), p.1069-1083
Main Authors: Abd El-Halim, H. F., Omar, M. M., Anwar, Mahmoud N.
Format: Article
Language:English
Subjects:
Aminophenol
Ampicillin
Analysis
Analytical Chemistry
Anticancer properties
Antiinfectives and antibacterials
Antimicrobial agents
Bacteria
Cadmium
Cadmium compounds
Cancer
Cancer treatment
Chemistry
Chemistry and Materials Science
Cobalt
Colon
Colon cancer
Coordination compounds
Copper
E coli
Fungi
Fungicides
Health screening
Imines
Inorganic Chemistry
Ligands
Measurement Science and Instrumentation
Nickel
Nonelectrolytes
Physical Chemistry
Polymer Sciences
Quinoline
Resistance
Schiff bases
Streptococcus infections
Thermal analysis
X-ray diffraction
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Summary:A new Schiff base ligand (HL) derived from quinoline-2-carboxaldehyde with 2-aminophenol (1:1 molar ratio) and its mixed ligand complexes, viz. 2,2′-bipyridine (1:1:1 molar ratio), have been synthesized and characterized by elemental analysis, spectroscopic studies, X-ray diffraction, ESR, magnetic and thermal analysis. The molar conductance measurement of mixed ligand complexes in DMF showed that Zn(II) and Cd(II) complexes were nonelectrolytes; however, Cr(III), Mn(II), Fe(III), Co(II), Ni(II) and Cu(II) complexes were electrolytes. The transition metal complexes had octahedral geometry with a general molecular formulae [M(L)(2,2′-bipy)(H 2 O)]Cl x · n H 2 O (M = Cr(III) ( x  =  n  = 2), Mn(II) and Co(II) ( x  = 1, n  = 0), Ni(II) and Cu(II) ( x  =  n  = 1) and [M(L)(2,2′-bipy)Cl]Cl x · n H 2 O (M = Fe(III) ( x  = 1, n  = 3), Zn(II) ( x  = 0, n  = 1) and Cd(II) ( x  = 0, n  = 2)). Also, Schiff base ligand and its mixed ligand complexes were screened against Gram-positive bacteria ( Streptococcus pneumoniae , Bacillus subtilis ), Gram-negative bacteria ( Pseudomonas aeruginosa , Escherichia coli ) and fungal species ( Aspergillus fumigatus , Candida albicans ). Gentamicin, ampicillin and amphotericin B were used as standard drugs for Gram positive, Gram negative and antifungal activity, respectively. The results showed that all mixed ligand complexes have antimicrobial activity higher than free Schiff base ligand. In addition, anticancer activity of Schiff base ligand and its mixed ligand metal complexes were also tested against breast cancer cell line (MCF-7) and colon cancer cell line (HCT-116). Cd(II) complex showed the highest IC 50 against two cell lines.
ISSN:1388-6150
1588-2926
DOI:10.1007/s10973-017-6491-1