Take a deep breath and digest the material: organoids and biomaterials of the respiratory and digestive systems

Human organoid models recapitulate many aspects of the complex composition and function of native organs. One of the main challenges in developing these models is the growth and maintenance of three-dimensional tissue structures and proper cellular organization that enable function. Biomaterials pla...

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Bibliographic Details
Published in:MRS communications 2017-09, Vol.7 (3), p.502-514
Main Authors: Dye, Briana R., Kasputis, Tadas, Spence, Jason R., Shea, Lonnie D.
Format: Article
Language:English
Subjects:
Adhesives
Biomaterials
Biomaterials for 3D Cell Biology Prospective Article
Biomedical engineering
Biomedical materials
Cellular structure
Characterization and Evaluation of Materials
Collagen
Digestive system
Hydrogels
Materials Engineering
Materials Science
Medicine
Nanotechnology
ORGANOIDS/SPHEROIDS
Organs
Polyethylene glycol
Polymer Sciences
Stem cells
Surgical implants
Three dimensional models
Transplants & implants
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Description
Summary:Human organoid models recapitulate many aspects of the complex composition and function of native organs. One of the main challenges in developing these models is the growth and maintenance of three-dimensional tissue structures and proper cellular organization that enable function. Biomaterials play an important role by providing a defined and tunable three-dimensional environment that is required for complex cellular organization and organoid growth in vitro or in vivo. This review summarizes organoids of the respiratory and digestive system, and the use of biomaterials to improve upon these model systems.
ISSN:2159-6859
2159-6867
DOI:10.1557/mrc.2017.61