Reduction of nitric oxide and DNA/RNA oxidation products are associated with active disease in systemic lupus erythematosus patients

The aims of the present study were to evaluate biomarkers of oxidative and nitrosative stress in systemic lupus erythematosus (SLE) patients, in particular products of DNA/RNA oxidative damage and their correlation with disease activity. This study included 188 controls and 203 patients; 153 with in...

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Bibliographic Details
Published in:Lupus 2017-09, Vol.26 (10), p.1106-1111
Main Authors: Iriyoda, T M V, Stadtlober, N, Lozovoy, M A B, Delongui, F, Costa, N T, Reiche, E M V, Dichi, I, Simão, A N C
Format: Article
Language:English
Subjects:
Adult
Antioxidants - metabolism
Biomarkers - metabolism
Butyl hydroperoxide
Case-Control Studies
Chemiluminescence
Deoxyribonucleic acid
Disease Progression
DNA
DNA - metabolism
DNA damage
Female
Glucocorticoids - therapeutic use
Humans
Kidneys
Linear Models
Lipid peroxidation
Lupus
Lupus Erythematosus, Systemic - drug therapy
Lupus Erythematosus, Systemic - physiopathology
Male
Metabolites
Middle Aged
Nitric oxide
Nitric Oxide - metabolism
Nitrosative Stress - physiology
Oxidation
Oxidation-Reduction
Oxidative stress
Oxidative Stress - physiology
Prednisone
Remission
Ribonucleic acid
RNA
RNA - metabolism
Severity of Illness Index
Systemic lupus erythematosus
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Summary:The aims of the present study were to evaluate biomarkers of oxidative and nitrosative stress in systemic lupus erythematosus (SLE) patients, in particular products of DNA/RNA oxidative damage and their correlation with disease activity. This study included 188 controls and 203 patients; 153 with inactive SLE (SLEDAI 
ISSN:0961-2033
1477-0962
DOI:10.1177/0961203317692436