Imaging of nuclear Overhauser enhancement at 7 and 3ￂ T

Nuclear Overhauser enhancement (NOE) is a type of magnetization transfer using cross-relaxation. It originates from mobile macromolecules, which may have relevance to the evaluation of tumor features. We studied the value of NOE imaging at 7 and 3 T and suggest a utility for diagnosing human brain t...

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Bibliographic Details
Published in:NMR in biomedicine 2017-09, Vol.30 (9)
Main Authors: Shen, Yuanyu, Xiao, Gang, Shen, Zhiwei, Zhang, Xiaolei, Tang, Xiangyong, Hu, Wei, Zhang, Zhiyan, Guan, Jitian, Wu, Renhua
Format: Article
Language:English
Subjects:
Benign
Biological products
Brain
Brain cancer
Brain tumors
Cross relaxation
Dependence
Image acquisition
Macromolecules
Medical imaging
Neuroimaging
pH effects
Substantia alba
Substantia grisea
Tumors
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Summary:Nuclear Overhauser enhancement (NOE) is a type of magnetization transfer using cross-relaxation. It originates from mobile macromolecules, which may have relevance to the evaluation of tumor features. We studied the value of NOE imaging at 7 and 3 T and suggest a utility for diagnosing human brain tumors. Two types of protein solution at different concentrations and pH values, and six normal Sprague Dawley (SD) rats, were used to detect NOE signal with a 7 T scanner. Then, six healthy volunteers and 11 patients with brain tumors (six gliomas and five meningiomas) were included at 3 T. Z-spectra were measured and NOE weighted (NOE*) images were acquired with a three-offset measurement. Wide spectral separation was shown at both 7 T and 3 T delineating the NOE peak in the Z-spectrum. The concentration dependence and pH independence of NOE were confirmed in phantom experiments, and NOE values were greater in white matter than in gray matter in vivo. At 3 T, data indicated that NOE* maps were slightly hypointense in gliomas and were not obviously different from meningiomas. Thus, NOE imaging may help distinguish benign from malignant tumors, and as such may contribute to diagnosing brain tumors.
ISSN:0952-3480
1099-1492
DOI:10.1002/nbm.3735