D28 THE WEB OF OMICS: DNA, RNA, AND PROTEIN MODIFICATIONS: The Alveolar Macrophage Toponome Is Altered By Sp-A1 Treatment

In our previous studies we have shown that the innate host defense molecules, human (h) surfactant protein-A1 (SP-A1) & SP-A2, differentially affect the proteomic expression profile and function of alveolar macrophages (AM). A further understanding of the hierarchical structure of the clustered...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Phelps, D S, Floros, J
Format: Article
Language:English
Subjects:
Gender differences
Proteins
Rodents
Online Access:Get full text
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Summary:In our previous studies we have shown that the innate host defense molecules, human (h) surfactant protein-A1 (SP-A1) & SP-A2, differentially affect the proteomic expression profile and function of alveolar macrophages (AM). A further understanding of the hierarchical structure of the clustered proteins, i.e. identifying the key protein responsible for CMP integrity and consequently function could provide the basis of translational research for therapeutic targets.
ISSN:1073-449X
1535-4970