C27 LET'S PRETEND WE'RE MARRIED: THE RIGHT VENTRICLE AND THE PULMONARY VASCULATURE: Endothelial Cell Hypoxia-Inducible Factor (hif) Activity Is Necessary For Right Ventricular Remodeling In A Murine Model Of Chronic-Hypoxic Pulmonary Hypertension

C27 LET'S PRETEND WE'RE MARRIED: THE RIGHT VENTRICLE AND THE PULMONARY VASCULATURE: Endothelial Cell Hypoxia-Inducible Factor (hif) Activity Is Necessary For Right Ventricular Remodeling In A Murine Model Of Chronic-Hypoxic Pulmonary Hypertension

Endothelial cell (EC) expression of HIF-1 is necessary for adaptive LV remodeling during chronic pressure overload, with loss of EC-specific HIF-1 activity associated with reduced LV capillary density. Conditional transgenic mice lacking expression of the obligate HIF-1a/HIF-2a co-factor ARNT (aryl...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Kolb, T M, Singer, B D, D'Alessio, F R, Damarla, M, Damico, R L, Hassoun, P M, Semenza, G, Shimoda, L
Format: Article
Language:eng
Subjects:
Angiogenesis
Hypoxia
Pulmonary hypertension
Rodents
Online Access:Get full text
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Summary:Endothelial cell (EC) expression of HIF-1 is necessary for adaptive LV remodeling during chronic pressure overload, with loss of EC-specific HIF-1 activity associated with reduced LV capillary density. Conditional transgenic mice lacking expression of the obligate HIF-1a/HIF-2a co-factor ARNT (aryl hydrocarbon receptor nuclear translocator) in Tie2+ lineage cells (ARNTf1/f1;Tie2-Cre+) and ARNT-expressing control mice (ARNTf1/f1;Tie2-Cre-) were exposed to normobaric hypoxia (10% FiO2) for 1-5 weeks.
ISSN:1073-449X
1535-4970