A74 REGULATORY MECHANISMS OF THE MOLECULAR PATHWAYS IN FIBROSIS: Activation Of Adenylyl Cyclase/camp Pathway Attenuates Tgf-β Transcriptional Response In Human Lung Fibroblasts Via Epac

Conclusions: Activation of the adenylyl cyclase/cAMP pathway attenuates TGF-ß-induced gene transcription in normal human lung fibroblasts. The beneficial effects of AC/cAMP pathway inhibiting the TGF-ß-target gene transcription is mediated predominantly via EPAC activation and is independent of the...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Witt, L J, Ansbro, B, Nigdelioglu, R, Wu, D, Meliton, A Y, Woods, P S, Sun, K A, Dulin, N O, Hamanaka, R B, Mutlu, G M
Format: Article
Language:English
Subjects:
Collagen
Fibroblasts
Gene expression
Kinases
Phosphorylation
Proteins
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Summary:Conclusions: Activation of the adenylyl cyclase/cAMP pathway attenuates TGF-ß-induced gene transcription in normal human lung fibroblasts. The beneficial effects of AC/cAMP pathway inhibiting the TGF-ß-target gene transcription is mediated predominantly via EPAC activation and is independent of the canonical TGF-ß/SMAD pathway.
ISSN:1073-449X
1535-4970