A47 NEW CONCEPTS IN COPD EXACERBATIONS: Lung Microbiome Analysis And Stochastic Modeling In The Aeris Study Identify Bacterial Profiles And Repetition Of Eosinophilic And Bacterial COPD Exacerbations

Exacerbations with different phenotypes (containing bacterial pathogens detected by culture compared to eosinophils in sputum) had significantly distinct ratios of Proteobacteria to Firmicutes. [...]using a Markov chain analysis of exacerbation phenotypes, we found that bacterial and eosinophilic (p...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Mayhew, D, Devos, N, Lambert, C, Brown, J, Magid-Slav, M, Miller, B, Nozay, F, Patel, R, Sathe, G, Simola, D, Staples, K J, Sung, R, Tal-Singer, R, Van Horn, S, Weynants, V, Devaster, J-M, Wilkinson, T
Format: Article
Language:English
Subjects:
Chronic obstructive pulmonary disease
Markov analysis
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Summary:Exacerbations with different phenotypes (containing bacterial pathogens detected by culture compared to eosinophils in sputum) had significantly distinct ratios of Proteobacteria to Firmicutes. [...]using a Markov chain analysis of exacerbation phenotypes, we found that bacterial and eosinophilic (p=9.25E-11 and 1.42E-3, respectively) but not viral (p=0.141) exacerbations were more likely to be repeated in subsequent exacerbations within a subject. [...]we analyzed the temporal stability of the lung microbiome within each subject and found that microbiome composition in both stable and exacerbation states became more variable in patients experiencing exacerbations during the year.
ISSN:1073-449X
1535-4970