A67 BREAKDOWN: THE CELLULAR CONTRIBUTION TO PULMONARY HYPERTENSION: Citrulline Supports Mitochondrial Respiration In Human Lung Endothelial Cells And Suggests Crosstalk Between Nitric Oxide And Tricarboxylic Acid Cycles

[...]citrulline did not appear to support significant production of extracellular organic acids (e.g., lactate). [...]at high oxygen consumption rates the TCA cycle appears to be depleted, suggesting that a rate-limiting step is occurring either at the generation of cytosolic intermediates or their...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: Kocurek, E G, Fessel, J P
Format: Article
Language:English
Subjects:
Carbon
Hypertension
Metabolism
Nitric oxide
Respiration
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Summary:[...]citrulline did not appear to support significant production of extracellular organic acids (e.g., lactate). [...]at high oxygen consumption rates the TCA cycle appears to be depleted, suggesting that a rate-limiting step is occurring either at the generation of cytosolic intermediates or their transport into the mitochondrion.
ISSN:1073-449X
1535-4970