D101 MECHANISTIC AND TRANSLATIONAL STUDIES IN COPD: The Role Of Dicer In Alveolar Macrophages And Dendritic Cells In Smoke-Induced Inflammation

RESULTS Cigarette smoke exposure in control mice resulted in an increase in the number of cells in BAL fluid, caused by elevated numbers of neutrophils, macrophages, DCs (both CD11b+ DCs and CD103+ DCs), CD4+ and CD8+ T-lymphocytes. CONCLUSIONS Absence of DICER in CD11c+ alveolar macrophages and den...

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Bibliographic Details
Published in:American journal of respiratory and critical care medicine 2017-01, Vol.195
Main Authors: De Smet, E G, Mestdagh, P, Provoost, S, Seys, L M, Joos, G F, Vermaelen, K, Brusselle, G G, Bracke, K R
Format: Article
Language:English
Subjects:
Chronic obstructive pulmonary disease
Dendritic cells
Gene expression
Inflammation
Lungs
Lymphatic system
Lymphocytes
Neutrophils
Pathogenesis
Rodents
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Summary:RESULTS Cigarette smoke exposure in control mice resulted in an increase in the number of cells in BAL fluid, caused by elevated numbers of neutrophils, macrophages, DCs (both CD11b+ DCs and CD103+ DCs), CD4+ and CD8+ T-lymphocytes. CONCLUSIONS Absence of DICER in CD11c+ alveolar macrophages and dendritic cells alters inflammatory responses in BAL fluid, lung and lymph nodes upon CS-exposure in mice.
ISSN:1073-449X
1535-4970