Propofol‐induced acute pancreatitis

Summary What is known and objective Drug‐induced acute pancreatitis comprises only 0.5%‐2% of all cases of acute pancreatitis. Propofol is a potentially dangerous drug that can cause acute pancreatitis, but this complication is extremely rare. Case summary A 57‐year‐old patient developed acute pancr...

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Bibliographic Details
Published in:Journal of clinical pharmacy and therapeutics 2017-08, Vol.42 (4), p.495-498
Main Authors: Csomor, J., Murínová, I., Broulíková, K., Kučerka, O., Sedloň, P., Jarošek, J., Urbánek, P., Zavoral, M.
Format: Article
Language:English
Subjects:
adverse drug reaction
Anesthetics, Intravenous - administration & dosage
Anesthetics, Intravenous - adverse effects
drug‐induced acute pancreatitis
Fatal Outcome
Female
Humans
Middle Aged
Pancreatitis
Pancreatitis, Acute Necrotizing - chemically induced
Propofol
Propofol - administration & dosage
Propofol - adverse effects
Surgery
Thyroidectomy
Thyroidectomy - methods
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Summary:Summary What is known and objective Drug‐induced acute pancreatitis comprises only 0.5%‐2% of all cases of acute pancreatitis. Propofol is a potentially dangerous drug that can cause acute pancreatitis, but this complication is extremely rare. Case summary A 57‐year‐old patient developed acute pancreatitis after a planned thyroidectomy. As the common causes of acute pancreatitis were excluded, we believe that the pancreatitis was drug‐induced, in this case by a single dose of propofol administered to the patient during the surgery. What is new and conclusion We present a rare case of propofol‐induced acute necrotising pancreatitis, which is to the best of our knowledge the first fatal case reported in an adult patient. Drug‐induced acute pancreatitis comprises only 0.5‐2% of all cases of acute pancreatitis. Propofol is a potentially dangerous drug that can cause acute pancreatitis, but this complication is extremely rare. We present a very rare case of propofol induced acute necrotising pancreatitis, which is to the best of our knowledge the first fatal case reported in an adult patient.
ISSN:0269-4727
1365-2710
DOI:10.1111/jcpt.12524