Effect of Magnesium and Osteoblast Cell Presence on Hydroxyapatite Formation on (Ti,Mg)N Thin Film Coatings

TiN and (Ti,Mg)N thin film coatings were deposited on Ti substrates by an arc-physical vapor deposition technique. The effect of cell presence on hydroxyapatite (HA) formation was investigated using surfaces with four different Mg contents (0, 8.1, 11.31, and 28.49 at.%). Accelerated corrosion above...

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Bibliographic Details
Published in:JOM (1989) 2017-07, Vol.69 (7), p.1195-1205
Main Authors: Onder, Sakip, Calikoglu-Koyuncu, Ayse Ceren, Torun Kose, Gamze, Kazmanli, Kursat, Kok, Fatma Nese, Urgen, Mustafa
Format: Article
Language:English
Subjects:
Arc deposition
Biocompatibility
Biomedical materials
Cell culture
Cell growth
Chemistry/Food Science
Coatings
Corrosion
Corrosion effects
Crystallinity
Doping
Earth Sciences
Engineering
Environment
Fourier transforms
Hydroxyapatite
Magnesium
Materials science
Mineralization
Physical vapor deposition
Physics
Scanning electron microscopy
Studies
Substrates
Thin film coatings
Thin films
Titanium nitride
Transplants & implants
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Summary:TiN and (Ti,Mg)N thin film coatings were deposited on Ti substrates by an arc-physical vapor deposition technique. The effect of cell presence on hydroxyapatite (HA) formation was investigated using surfaces with four different Mg contents (0, 8.1, 11.31, and 28.49 at.%). Accelerated corrosion above 10 at.% Mg had a negative effect on the performance in terms of both cell proliferation and mineralization. In the absence of cells, Mg-free TiN coatings and low-Mg (8.1 at.%)-doped (Ti,Mg)N surfaces led to an early HA deposition (after 7 days and 14 days, respectively) in cell culture medium (DMEM), but the crystallinity was low. More crystalline HA structures were obtained in the presence of the cells. HA deposits with an ideal Ca/P ratio were obtained at least a week earlier, at day 14, in TiN and low-Mg (8.1 at.%)-doped (Ti,Mg)N compared with that of high-Mg-containing surfaces (>10 at.%). A thicker mineralized matrix was formed on low-Mg (8.1 at.%)-doped (Ti,Mg)N relative to that of the TiN sample. Low-Mg doping (
ISSN:1047-4838
1543-1851
DOI:10.1007/s11837-016-2029-4