On Demand Sildenafil as a Treatment of Raynaud’s Phenomenon: A Series of N-of-1 Trials

Background Continuous treatment of Raynaud’s phenomenon (RP) with phosphodiesterase-5 inhibitors has shown moderate efficacy (1). [...]patients with RP may not be willing to take a long-term treatment; as RP attacks are usually triggered by exposure to cold, “as required” single doses before/during...

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Bibliographic Details
Published in:Clinical therapeutics 2017-08, Vol.39 (8), p.e4-e4
Main Authors: Roustit, M, Giai, J, Gaget, O, Mouhib, M, Lotito, A, Khouri, C, Blaise, S, Seinturier, C, Subtil, F, Imbert, B, Carpentier, P.H, Vohra, S, Cracowski, J.L
Format: Article
Language:English
Subjects:
Background radiation
Clinical trials
Exposure
Internal Medicine
Medical Education
Phosphodiesterase
Sildenafil
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Summary:Background Continuous treatment of Raynaud’s phenomenon (RP) with phosphodiesterase-5 inhibitors has shown moderate efficacy (1). [...]patients with RP may not be willing to take a long-term treatment; as RP attacks are usually triggered by exposure to cold, “as required” single doses before/during exposure may be a good alternative. Mixed models...
ISSN:0149-2918
1879-114X
DOI:10.1016/j.clinthera.2017.05.015