Associations between polymorphisms in the NICD domain of bovine NOTCH1 gene and growth traits in Chinese Qinchuan cattle

NOTCH1 is one of the four mammalian Notch receptors, which is involved in the Notch signaling pathway. Specifically, NOTCH1 promotes the proliferation of myogenic precursor cells, and the NICD domain of NOTCH1 can impair regeneration of skeletal muscles. However, similar research on the bovine NOTCH...

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Bibliographic Details
Published in:Journal of applied genetics 2017-05, Vol.58 (2), p.241-247
Main Authors: Liu, Mei, Zhang, Chenge, Lai, Xinsheng, Xue, Jing, Lan, Xianyong, Lei, Chuzhao, Jia, Yutang, Chen, Hong
Format: Article
Language:English
Subjects:
Analysis
Animal Genetics and Genomics
Animal Genetics • Original Paper
Animal husbandry
Association analysis
Beef cattle
Biomedical and Life Sciences
Body height
Body weight
Breeding
Cattle
Cell proliferation
Deoxyribonucleic acid
DNA
DNA sequencing
Genes
Genetic aspects
Growth
Haplotypes
Hip
Human Genetics
Identification methods
Life Sciences
Microbial Genetics and Genomics
Muscles
Notch1 protein
Nucleotide sequencing
Plant Genetics and Genomics
Polymerase chain reaction
Receptors
Regeneration
Restriction fragment length polymorphism
Signal transduction
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Skeletal muscle
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Summary:NOTCH1 is one of the four mammalian Notch receptors, which is involved in the Notch signaling pathway. Specifically, NOTCH1 promotes the proliferation of myogenic precursor cells, and the NICD domain of NOTCH1 can impair regeneration of skeletal muscles. However, similar research on the bovine NOTCH1 gene is lacking. In this study, we detected the polymorphisms of the bovine NOTCH1 gene in a total of 448 individuals from Chinese Qinchuan cattle with DNA pooling, forced PCR-RFLP, and DNA sequencing methods. Five novel SNPs were identified within the NICD domain, and eight haplotypes comprising combinations of these five SNPs were studied as well. The association analysis of SNPs’ effects with growth traits revealed that g.A48250G was significantly associated with body height, body weight, and height at hip cross, and that g.A49239C only showed significant associations with body height. This suggests that the NOTCH1 gene is a strong candidate gene that could be utilized as a promising marker in beef cattle breeding programs.
ISSN:1234-1983
2190-3883
DOI:10.1007/s13353-016-0377-y