Ameliorative Potential of Prepartal Trace Mineral and Vitamin Supplementation on Parturition-Induced Redox Balance and Myeloperoxidase Activity of Periparturient Sahiwal Cows

Twelve apparently healthy multiparous parturient Sahiwal cows were allocated into two groups having six cows in each one. Six cows were supplemented with antioxidant mixture (mixture containing Cu, Mn, Cr, Zn, and vitamins A and D3) daily from 21 days before parturition till the day relative to calv...

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Published in:Biological trace element research 2017-05, Vol.177 (1), p.72-79
Main Authors: Yadav, Brajesh K., Singh, Shanker K., Nakade, Udayraj P., Singh, Vivek K., Sharma, Abhishek, Srivastava, Mukesh, Yadav, Brijesh, Singh, Yajuvendra, Sirohi, Rajneesh, Garg, Satish K.
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Antioxidants - metabolism
Biochemistry
Biomedical and Life Sciences
Biotechnology
Cattle
Chromium
Copper
Dietary Supplements
Life Sciences
Lipid peroxidation
Minerals - administration & dosage
Minerals - blood
Nutrition
Oncology
Oxidation-Reduction
Peroxidase - metabolism
Proteins
Trace Elements - administration & dosage
Trace Elements - blood
Vitamins - administration & dosage
Vitamins - blood
Zinc
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Summary:Twelve apparently healthy multiparous parturient Sahiwal cows were allocated into two groups having six cows in each one. Six cows were supplemented with antioxidant mixture (mixture containing Cu, Mn, Cr, Zn, and vitamins A and D3) daily from 21 days before parturition till the day relative to calving. Whereas, remaining non-supplemented six cows were kept as the control group. Blood samples were obtained five times: at enrolment (21 days pre-partum), and again at days 0, +7, +14, and +21 relative to calving. In the non-supplemented control group, serum total antioxidant capacity (TAC) was significantly lower at days 0, +7, and +14 as compared to their own day −21 values. Likewise, significantly lower myeloperoxidase (MPO) activities were also exhibited by these cows at days 0 and +7. Conversely, serum malondialdehyde (MDA) and protein carbonyl (PC) levels were significantly higher in these cows at days 0, +7, +14, and +21. However, significant alterations in TAC content among the studied sampling days were not recorded in antioxidants supplemented group. Moreover, TAC content and MPO activities of supplemented group were significantly higher at days 0, +7, and +14 when compared with that of the non-supplemented control group. However, MDA and PC contents of supplemented group were significantly lower at days 0, +7, +14, and +21 as compared to that of the non-supplemented control group. In conclusion, periparturient Sahiwal cows experience substantial oxidative and immunological dents which can be potentially ameliorated by prepartal trace mineral and vitamin supplementation.
ISSN:0163-4984
1559-0720
DOI:10.1007/s12011-016-0864-3