Synthesis of novel 3-substituted pyridothienopyrimidine derivatives with biological evaluation as antimicrobial agents

Novel 3-substituted pyridothienopyrimidine derivatives have been synthesized via the reaction of 2-{7,9-dimethyl-4-oxopyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-3(4 H )-yl}acetohydrazide( 5 ) with a variety of active reagents and chemicals. Structures of the newly synthesized compounds were established...

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Bibliographic Details
Published in:Chemical research in Chinese universities 2016-12, Vol.32 (6), p.967-972
Main Authors: El-Essawy, Farag A., Boshta, Nader M., El-Sawaf, Ayman K., Nassar, Amal A., Khalafallah, Mohamed S.
Format: Article
Language:English
Subjects:
Analytical Chemistry
Antiinfectives and antibacterials
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Inorganic Chemistry
Organic Chemistry
Physical Chemistry
Reagents
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Summary:Novel 3-substituted pyridothienopyrimidine derivatives have been synthesized via the reaction of 2-{7,9-dimethyl-4-oxopyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-3(4 H )-yl}acetohydrazide( 5 ) with a variety of active reagents and chemicals. Structures of the newly synthesized compounds were established based on spectral data. The resulting pyridothienopyrimidine derivatives were evaluated for their possible antimicrobial activity and some of them represent a new class of potentially antimicrobial compounds, especially compounds 9 and 18 which displayed the highest activity against Gram-positive bacteria, Gram-negative bacteria, and Fungi in MIC range of 0.12―1.95 μg/mL.
ISSN:1005-9040
2210-3171
DOI:10.1007/s40242-016-6218-z