PRO-ATHEROGENIC PROPERTIES OF PLASMA FROM PATIENTS WITH TYPE 1 DIABETES MELLITUS: EFFECTS ON MACROPHAGE LIPID HANDLING

Cholesterol transport protein mRNA was quantified by real-time RT-PCR using specific primers for each gene Cholesterol efflux and oxidized LDL uptake were measured. Results: THP-1 macrophages exposed to T1DM plasma displayed downregulation of reverse cholesterol transport proteins 27-hydroxylase, AB...

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Bibliographic Details
Published in:Journal of the American College of Cardiology 2017-03, Vol.69 (11), p.2067-2067
Main Authors: DeLeon, Joshua R, Corletto, Jorge Mejia, Accacha, Siham, Voloshyna, Iryna, Siegart, Nicolle, Kasselman, Lora, Magana, Mariano Castro, Reiss, Allison
Format: Article
Language:English
Subjects:
Atherosclerosis
Cardiology
Cardiovascular
Cholesterol
Diabetes
Gene expression
Internal Medicine
Lipids
Plasma
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Summary:Cholesterol transport protein mRNA was quantified by real-time RT-PCR using specific primers for each gene Cholesterol efflux and oxidized LDL uptake were measured. Results: THP-1 macrophages exposed to T1DM plasma displayed downregulation of reverse cholesterol transport proteins 27-hydroxylase, ABCA1 and LXR and increased scavenger receptor (SR) expression.
ISSN:0735-1097
1558-3597
DOI:10.1016/S0735-1097(17)35456-6