Liver and biliary damages following transarterial chemoembolization of hepatocellular carcinoma: comparison between drug-eluting beads and lipiodol emulsion

Objectives To compare transarterial chemoembolization (TACE)-related hepatic toxicities of conventional TACE (cTACE) and drug-eluting beads TACE (DEB-TACE) in patients with intermediate-stage hepatocellular carcinoma. Methods In this retrospective study, 151 consecutive patients undergoing cTACE or...

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Bibliographic Details
Published in:European radiology 2017-04, Vol.27 (4), p.1431-1439
Main Authors: Monier, Arnaud, Guiu, Boris, Duran, Rafael, Aho, Serge, Bize, Pierre, Deltenre, Pierre, Dunet, Vincent, Denys, Alban
Format: Article
Language:English
Subjects:
Aged
Bile Duct Diseases - diagnostic imaging
Bile Duct Diseases - etiology
Bile Duct Diseases - physiopathology
Bile Ducts - diagnostic imaging
Bile Ducts - physiopathology
Carcinoma, Hepatocellular - therapy
Chemoembolization, Therapeutic - adverse effects
Chemoembolization, Therapeutic - methods
Chemotherapy
Diagnostic Radiology
Drug dosages
Embolization
Ethiodized Oil - administration & dosage
Ethiodized Oil - adverse effects
Female
Humans
Imaging
Internal Medicine
Interventional
Interventional Radiology
Liver - diagnostic imaging
Liver - physiopathology
Liver cancer
Liver Cirrhosis - diagnostic imaging
Liver Cirrhosis - etiology
Liver Diseases - diagnostic imaging
Liver Diseases - etiology
Liver Diseases - physiopathology
Liver Neoplasms - therapy
Magnetic Resonance Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Neuroradiology
Radiology
Retrospective Studies
Thrombosis
Toxicity
Ultrasound
Veins & arteries
Venous Thrombosis - diagnostic imaging
Venous Thrombosis - etiology
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Summary:Objectives To compare transarterial chemoembolization (TACE)-related hepatic toxicities of conventional TACE (cTACE) and drug-eluting beads TACE (DEB-TACE) in patients with intermediate-stage hepatocellular carcinoma. Methods In this retrospective study, 151 consecutive patients undergoing cTACE or DEB-TACE and MRI 3-6 weeks before and after therapy were included. Toxicity was assessed on imaging (global hepatic damages (GHD), overall biliary injuries, biliary cast, bile duct dilatation, intrahepatic biloma, portal thrombosis), and clinico-biological follow-ups. Tumour response, time to progression (TTP), and overall survival were assessed. Factors influencing complication rate were identified by generalized equation logistic regression model. Results Biliary injuries and intrahepatic biloma incidence were significantly higher following DEB-TACE ( p  
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-016-4488-y