Synthesis and antimicrobial activity of new piperazine-based heterocyclic compounds

The hydrazide , that was obtained from 1-(4-fluorophenyl)piperazine ( ), was converted to the corresponding carbothioamides by the reaction with alkyl(aryl) isothiocyanates. The synthesis of conazole analogs was performed via the intermediary of triazoles . The condensation of triazoles with several...

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Bibliographic Details
Published in:Heterocyclic communications 2017-02, Vol.23 (1), p.43-54
Main Authors: Basoglu Ozdemir, Serap, Uygun Cebeci, Yıldız, Bayrak, Hacer, Mermer, Arif, Ceylan, Sule, Demirbas, Ahmet, Alpay Karaoglu, Sengul, Demirbas, Neslihan
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
antimicrobial activity
Antimicrobial agents
Chemical synthesis
conazole
Heterocyclic amines
Heterocyclic compounds
Mannich base
microwave
piperazine
Triazoles
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Summary:The hydrazide , that was obtained from 1-(4-fluorophenyl)piperazine ( ), was converted to the corresponding carbothioamides by the reaction with alkyl(aryl) isothiocyanates. The synthesis of conazole analogs was performed via the intermediary of triazoles . The condensation of triazoles with several heterocyclic amines in the presence of formaldehyde afforded the corresponding -aminoalkylated triazoles . The effect of different catalysts and solvents on conventional and microwave (MW)-prompted reactions was examined. The synthesized compounds were screened for their antimicrobial activities.
ISSN:0793-0283
2191-0197
DOI:10.1515/hc-2016-0125