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Cytokine Release from Peripheral Blood Mononuclear Cells upon Stimulation with the Culprit Drugs during Acute Stage of Severe Cutaneous Adverse Reactions

Methods Peripheral blood mononuclear cells (PBMCs) collected during acute stage in 15 SCAR patients (5 acute generalized exanthematous pustulosis-AGEP, 5 drug reaction with eosinophilia and systemic symptoms-DRESS, and 5 Stevens-Johnson syndrome/toxic epidermal necrolysis-SJS/TEN) were stimulated wi...

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Published in:Journal of allergy and clinical immunology 2017-02, Vol.139 (2), p.AB43-AB43
Main Authors: Klaewsongkram, Jettanong, MD, Thantiworasit, Pattarawat, MSc, Suthumchai, Nithikan, MSc, Rerknimitr, Pawinee, MD, Tuchinda, Papapit, MD, Chularojanamontri, Leena, MD, Rerkpattanapipat, Ticha, MD, Chanprapaph, Kumutnart, MD, Disphanurat, Wareeporn, MD, Chakkavittumrong, Panlop, MD, Tovanabutra, Napatra, MD, Srisuttiyakorn, Chutika, MD, Sukasem, Chonlaphat, B. Pharm, PhD, Srinoulprasert, Yuttana, PhD, MD
Format: Article
Language:English
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Summary:Methods Peripheral blood mononuclear cells (PBMCs) collected during acute stage in 15 SCAR patients (5 acute generalized exanthematous pustulosis-AGEP, 5 drug reaction with eosinophilia and systemic symptoms-DRESS, and 5 Stevens-Johnson syndrome/toxic epidermal necrolysis-SJS/TEN) were stimulated with the culprit drugs or non-allergic control drugs for 72 hours.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.12.198