Follicular Helper T (Tfh) Cells Mediate Peanut Allergy

[...]CD4-specific Bcl6 conditional knockout mice that are deficient in Tfh cells (but Th2-cell compartment is intact) were totally protected from developing peanut-specific IgE antibody and anaphylactic responses Conclusions Tfh cells, but unlikely Th2 cells, mediate production of specific IgE antib...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2017-02, Vol.139 (2), p.AB70-AB70
Main Authors: Kobayashi, Takao, PhD, Dolence, Joseph J., PhD, Iijima, Koji, PhD, Kita, Hirohito, MD
Format: Article
Language:English
Subjects:
Allergy and Immunology
Food allergies
Peanuts
Rodents
Online Access:Get full text
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Summary:[...]CD4-specific Bcl6 conditional knockout mice that are deficient in Tfh cells (but Th2-cell compartment is intact) were totally protected from developing peanut-specific IgE antibody and anaphylactic responses Conclusions Tfh cells, but unlikely Th2 cells, mediate production of specific IgE antibody in peanut allergy.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.12.277