ORAI1 Mutation in a Child with Primary Immunodeficiency-9

ORAI1 encodes for calcium release-activated calcium (CRAC) channels which are essential for antigen induced gene expression for T cell activation and proliferation via the NFAT-driven pathway and T cell migration and homing to lymph nodes.

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2017-02, Vol.139 (2), p.AB17-AB17
Main Authors: Patel, Snehal, DO, Carr, Tara F., MD, FAAAAI, Daines, Michael O., MD FAAAAI
Format: Article
Language:English
Subjects:
Allergy and Immunology
Gene expression
Lymphocytes
Mutation
Pneumonia
Online Access:Get full text
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Description
Summary:ORAI1 encodes for calcium release-activated calcium (CRAC) channels which are essential for antigen induced gene expression for T cell activation and proliferation via the NFAT-driven pathway and T cell migration and homing to lymph nodes.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2016.12.010