Clinical and biochemical factors associated with preeclampsia in women with obesity

Objective To compare early pregnancy clinical and biomarker risk factors for later development of preeclampsia between women with obesity (body mass index, BMI ≥30 kg/m2) and those with a normal BMI (20–25 kg/m2). Methods In 3,940 eligible nulliparous women from the Screening for Pregnancy Endpoints...

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Published in:Obesity (Silver Spring, Md.) Md.), 2017-02, Vol.25 (2), p.460-467
Main Authors: Vieira, Matias C., Poston, Lucilla, Fyfe, Elaine, Gillett, Alexandra, Kenny, Louise C., Roberts, Claire T., Baker, Philip N., Myers, Jenny E., Walker, James J., McCowan, Lesley M., North, Robyn A., Pasupathy, Dharmintra
Format: Article
Language:English
Subjects:
Adult
Algorithms
Biomarkers
Biomarkers - blood
Body mass index
Diabetes
Family medical history
Female
Gestational Age
Health risk assessment
Humans
Hypertension
Hypotheses
Insulin resistance
Obesity
Obesity - blood
Obesity - complications
Obesity - physiopathology
Parity
Placenta Growth Factor - blood
Pre-Eclampsia - blood
Preeclampsia
Pregnancy
Pregnancy Proteins
Proteins
Risk Factors
Urine
Uterine Artery - physiopathology
Vascular Resistance - physiology
Womens health
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Summary:Objective To compare early pregnancy clinical and biomarker risk factors for later development of preeclampsia between women with obesity (body mass index, BMI ≥30 kg/m2) and those with a normal BMI (20–25 kg/m2). Methods In 3,940 eligible nulliparous women from the Screening for Pregnancy Endpoints (SCOPE) study, a total of 53 biomarkers of glucose and lipid metabolism, placental function, and known markers of preeclampsia were measured at 14 to 16 weeks' gestation. Logistic regression was performed to identify clinical and biomarker risk factors for preeclampsia in women with and without obesity. Results Among 834 women with obesity and 3,106 with a normal BMI, 77 (9.2%) and 105 (3.4%) developed preeclampsia, respectively. In women with obesity, risk factors included a family history of thrombotic disease, low plasma placental growth factor, and higher uterine artery resistance index at 20 weeks. In women with a normal BMI, a family history of preeclampsia or gestational hypertension, mean arterial blood pressure, plasma endoglin and cystatin C, and uterine artery resistance index were associated with preeclampsia, while high fruit intake was protective. Conclusions Women with obesity and a normal BMI have different early pregnancy clinical and biomarker risk factors for preeclampsia.
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.21715