Activation of peripheral [kappa]-opioid receptors normalizes caffeine effects modified in nicotine-dependent rats during nicotine withdrawal

The study examined the effect of peripheral (intragastric) ICI-204,448, an agonist of gastric [kappa]-opioid receptors, on the psychostimulating and anxiolytic effects of caffeine in nicotine-dependent rats at the stage of nicotine withdrawal. In these rats, the effects of caffeine (10 mg/kg) were p...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2016-10, Vol.161 (6), p.743
Main Authors: Sudakov, S.K, Bogdanova, N.G
Format: Article
Language:English
Subjects:
Caffeine
Physiological aspects
Tranquilizing agents
Online Access:Get full text
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Summary:The study examined the effect of peripheral (intragastric) ICI-204,448, an agonist of gastric [kappa]-opioid receptors, on the psychostimulating and anxiolytic effects of caffeine in nicotine-dependent rats at the stage of nicotine withdrawal. In these rats, the effects of caffeine (10 mg/kg) were perverted. In nicotine-dependent rats, caffeine produced an anxiolytic effect accompanied by pronounced stimulation of motor activity, in contrast to anxiogenic effect induced by caffeine in intact rats without nicotine dependence. During nicotine withdrawal, nicotine-dependent rats demonstrated enhanced sensitivity to nicotine. Intragastric administration of [kappa]-opioid receptor agonist ICI-204,448 normalized the effect of caffeine in nicotine-dependent rats. We have previously demonstrated that activation of peripheral [kappa]-opioid receptors inhibited central [kappa]-opioid activity and eliminated manifestations of nicotine withdrawal syndrome in nicotine-dependent rats, e.g. metabolism activation, stimulation of motor activity, and enhancement of food consumption. In its turn, inhibition of central [kappa]-opioid structures activates the brain adenosine system, which can attenuate the caffeine-induced effects in nicotine-dependent rats. Key Words: nicotine; caffeine; motor activity; elevated plus-maze; endogenous opioid system
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-016-3499-7