TNF-[alpha] concentrations in pre-operative synovial fluid for predicting early post-operative function and pain after fast-track total knee arthroplasty

Background Tumor necrosis factor-alpha (TNF-α) helps regulate neuroinflammation and anxiety and could conceivable predict early post-operative pain and function after fast-track total knee arthroplasty (TKA). Methods In patients with severe osteoarthritic knees undergoing TKA, we assessed: the corre...

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Bibliographic Details
Published in:The knee 2016-12, Vol.23 (6), p.1044
Main Authors: Zietek, Pawel, Dziedziejko, Violetta, Safranow, Krzysztof, Zietek, Joanna, Stepien-Slodkowska, Marta, Bialecka, Monika, Zietek, Maciej, Kotrych, Daniel, Kaminski, Adam, Kowalska, Aleksandra
Format: Article
Language:English
Subjects:
Age
Analgesics
Anesthesia
Anxiety
Arthritis
Body mass index
Conflicts of interest
Gangrene
Hospitals
Joint surgery
Knee
Pain
Patients
Physiology
Rehabilitation
Society
Surgery
Tumor necrosis factor-TNF
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Summary:Background Tumor necrosis factor-alpha (TNF-α) helps regulate neuroinflammation and anxiety and could conceivable predict early post-operative pain and function after fast-track total knee arthroplasty (TKA). Methods In patients with severe osteoarthritic knees undergoing TKA, we assessed: the correlations between pre-operative concentrations of TNF-α in synovial fluid; pre- and six-week post-operative knee function and pain; pre- and post-operative anxiety; pre- and post-operative synovial fluid concentrations of cartilage oligomeric matrix protein (COMP); age and body mass index (BMI). Results Of 100 enrolled patients, 78 had evaluable TNF-α data, and 58 had evaluable COMP data. Pre-operative TNF-α concentrations were inversely correlated with post-operative pain scores during walking (rS=-0.26,P=0.03) and with change of pain at rest during six weeks after TKA (rs=-0.28,P=0.03) and were directly correlated with a higher post-operative Knee Society score (KSS) (rS=0.43,P
ISSN:0968-0160
1873-5800
DOI:10.1016/j.knee.2016.02.013