G202(P) A Survey of Necrotising Enterocolitis at a Tertiary Neonatal Unit

Aims Necrotising enterocolitis (NEC) is a gastrointestinal emergency occurring in approximately 1–3% of neonates admitted to intensive care units. It carries significant mortality (up to 50%) and an extensive range of short and long term complications. Despite decades of research, its pathogenesis r...

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Bibliographic Details
Published in:Archives of disease in childhood 2013-06, Vol.98 (Suppl 1), p.A91-A91
Main Authors: Wilcock, A, Victor, S
Format: Article
Language:English
Subjects:
Annual Reports
Attrition (Research Studies)
Neonates
Young Children
Online Access:Get full text
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Summary:Aims Necrotising enterocolitis (NEC) is a gastrointestinal emergency occurring in approximately 1–3% of neonates admitted to intensive care units. It carries significant mortality (up to 50%) and an extensive range of short and long term complications. Despite decades of research, its pathogenesis remains poorly understood, though current understanding suggests a multi-factorial aetiology. Indeed, prematurity, feeding practises, genetics, various maternal factors and certain neonatal morbidities have all been implicated in the pathogenesis of NEC. As there is a paucity of published surveys providing a general overview of NEC in the last decade, we aimed to provide a more current perspective in a tertiary neonatal unit. Methods Using diagnostic criteria outlined in the 11th BPSU Annual Report, 49 infants with NEC within a 13 month period were retrospectively identified. Subsequently, data from patient records (including maternal data) and imaging reports was extracted and analysed. The presence of various risk factors (including those mentioned above) and information regarding the presentation, diagnosis and management of NEC in these infants were recorded along with complication and mortality rates. Results Risk factors including intrauterine growth restriction (18.4%), patent ductus arteriosus (51%) and gastroschisis (10.2%) were highly prevalent within our cohort. Consistent with previous literature, 86% of infants were premature and 71.4% were very low birthweight infants (
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2013-304107.214