410 Perinatal Infection and Neurodevelopmental outcome in Very Preterm and Very Low Birthweight Infants: a Meta-Analysis

Backgrounds Very preterm birth and very low birth weight (VLBW) is associated with adverse neurodevelopmental outcome. Many very preterm/VLBW infants develop perinatal infections. This quantitative meta-analysis summarizes studies evaluating the effect of perinatal infections on neurodevelopmental o...

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Bibliographic Details
Published in:Archives of disease in childhood 2012-10, Vol.97 (Suppl 2), p.A120-A121
Main Authors: Vliet, EOG van, Kieviet, JF de, Oosterlaan, J, Elburg, RM van
Format: Article
Language:English
Subjects:
Body Weight
Cognitive Development
Meta Analysis
Motor Development
Young Children
Online Access:Get full text
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Summary:Backgrounds Very preterm birth and very low birth weight (VLBW) is associated with adverse neurodevelopmental outcome. Many very preterm/VLBW infants develop perinatal infections. This quantitative meta-analysis summarizes studies evaluating the effect of perinatal infections on neurodevelopmental outcome in this population. Methods We searched Medline, PsychInfo, EMBASE and Web of Knowledge for studies on infections and neurodevelopmental outcome measured with Bayley Scales of Infant Development 2nd edition (BSID-II) scores in very preterm/VLBW infants. Two authors independently reviewed, rated and abstracted data from each article. Results This meta-analysis includes 18 studies encompassing data on 13.755 very preterm/VLBW infants. Very preterm/VLBW infants with perinatal infections have poorer mental (–0.25 SD, p
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2012-302724.0410