The effect of surgical menopause on the intima-media thickness of the carotid and coronary arteries

Objective: To evaluate the effect of prior bilateral oophorectomy on the intima-media thickness (IMT) of coronary and carotid arteries. Methods: A total of 25 Wistar albino rats, aged 8-10 weeks, were assigned to three groups: ovariectomized (n = 10), control (n = 10) and sham (n = 5). The rats in t...

Full description

Saved in:
Bibliographic Details
Published in:Climacteric : the journal of the International Menopause Society 2016-10, Vol.19 (5), p.452-457
Main Authors: Ozdemirci, S., Kasapoglu, T., Dilbaz, B., Salgur, F., Duran, B., Koc, O., Unverdi, H., Hucumenoglu, S.
Format: Article
Language:English
Subjects:
Animals
Atherosclerosis
Carotid arteries
Carotid Arteries - pathology
Carotid artery
Carotid Intima-Media Thickness
coronary artery
Coronary vessels
Coronary Vessels - pathology
Female
intima-media thickness
Medical procedures
Menopause
Ovariectomy
Random Allocation
Rats
Rats, Wistar
Stents
Surgery
Veins & arteries
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective: To evaluate the effect of prior bilateral oophorectomy on the intima-media thickness (IMT) of coronary and carotid arteries. Methods: A total of 25 Wistar albino rats, aged 8-10 weeks, were assigned to three groups: ovariectomized (n = 10), control (n = 10) and sham (n = 5). The rats in the sham group only underwent midline laparotomy, while the other rats' ovaries were removed by the same type of laparotomy. All rats were sacrificed to evaluate microscopically the impact of a prolonged 26-week surgical menopause (menopausal period) on the IMT of the carotid and coronary arterial structure. Results: The mean IMTs of both the carotid and coronary arteries in the ovariectomized group were significantly thicker than those of the control and sham groups (carotid arteries: 268.69 ± 53.67, 195.61 ± 47.60 and 193.86 ± 75.01 μm, p = 0.014; coronary arteries: 182.40 ± 30.22, 136.00 ± 35.82 and 165.24 ± 40.68 μm, p = 0.022, respectively). Conclusion: According to the results of this study, surgical menopause results in a noteworthy increase in the IMT of the carotid and coronary arteries when compared with the controls. This interventional effect may have a significant role in accelerating the process of atherosclerosis.
ISSN:1369-7137
1473-0804
DOI:10.1080/13697137.2016.1212007