Serum thymosin [alpha] 1 levels in patients with chronic inflammatory autoimmune diseases

Summary Thymosin alpha 1 (T[alpha]1) is a powerful modulator of immunity and inflammation. Despite years of studies, there are a few reports evaluating serum T[alpha]1 in health and disease. We studied a cohort of healthy individuals in comparison with patients affected by chronic inflammatory autoi...

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Published in:Clinical and experimental immunology 2016-10, Vol.186 (1), p.39
Main Authors: Pica, F, Chimenti, M S, Gaziano, R, Bue, C, Casalinuovo, I A, Triggianese, P, Conigliaro, P, Di Carlo, D, Cordero, V, Adorno, G, Volpi, A, Perricone, R, Garaci, E
Format: Article
Language:English
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Summary:Summary Thymosin alpha 1 (T[alpha]1) is a powerful modulator of immunity and inflammation. Despite years of studies, there are a few reports evaluating serum T[alpha]1 in health and disease. We studied a cohort of healthy individuals in comparison with patients affected by chronic inflammatory autoimmune diseases. Sera from 120 blood donors (healthy controls, HC), 120 patients with psoriatic arthritis (PsA), 40 with rheumatoid arthritis (RA) and 40 with systemic lupus erythematosus (SLE), attending the Transfusion Medicine or the Rheumatology Clinic at the Policlinico Tor Vergata, Rome, Italy, were tested for T[alpha]1 content by means of a commercial enzyme-linked immunosorbent assay (ELISA) kit. Data were analysed in relation to demographic and clinical characteristics of patients and controls. A gender difference was found in the HC group, where females had lower serum T[alpha]1 levels than males (P
ISSN:0009-9104
1365-2249
DOI:10.1111/cei.12833