Heat shock protein-70 and hypoxia inducible factor-1[alpha] in type 2 diabetes mellitus patients complicated with retinopathy

Purpose To elucidate the role of heat shock protein-70 (HSP70) and hypoxia inducible factor-1[alpha] (HIF-1[alpha]) in diabetic retinopathy (DR) patients. Design and methods A comparative study was done on the serum level of both HSP70 and HIF-1[alpha] in 50 patients with type 2 diabetes mellitus (T...

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Published in:Acta ophthalmologica (Oxford, England) England), 2016-08, Vol.94 (5), p.e361
Main Authors: Sayed, Khulood M, Mahmoud, Aida A
Format: Article
Language:English
Subjects:
Ophthalmology
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Summary:Purpose To elucidate the role of heat shock protein-70 (HSP70) and hypoxia inducible factor-1[alpha] (HIF-1[alpha]) in diabetic retinopathy (DR) patients. Design and methods A comparative study was done on the serum level of both HSP70 and HIF-1[alpha] in 50 patients with type 2 diabetes mellitus (T2DM) without DR, 50 patients with T2DM and DR and 70 healthy control subjects. Results HSP70 and HIF-1[alpha] were significantly increased in T2DM patients compared to controls and increased in patients with T2DM & DR compared to T2DM patients without DR (p < 0.0001). HSP70 did not differ among the patients with different stages of DR, while HIF-1[alpha] increased significantly in grades 3 and 4 DR patients compared to grades 1 and 2 DR patients. A strong correlation was found between HIF-1[alpha] and the development of DR (r = 0.835, p = 0.00) but not with HSP70. HIF-1[alpha] can be used as a predictor for development of DR but not HSP70. Conclusions Our study was the first that investigated both HSP70 and HIF-1[alpha] in humans and was the first that measured their levels in serum of patients with DR. The study suggested that HSP70 might have a protective function in T2DM patients rather than a therapeutic function. HIF-1[alpha] had an upper hand in the development and progression of DR. Induction of HSP70 and blockage of HIF-1[alpha] could lead to the development of novel prophylactic and therapeutic strategies for DR and potentially other diabetic complications.
ISSN:1755-375X
1755-3768
DOI:10.1111/aos.12919