Removal from liver transplantation list of a hepatitis C virus‐HIV co‐infected patient after successful treatment with sofosbuvir and daclatasvir

We present a human immunodeficiency virus‐infected patient with severe decompensated hepatitis C virus‐related cirrhosis awaiting liver transplantation (LT) who received a 24‐week course of interferon/ribavirin‐free antiviral treatment with sofosbuvir and daclatasvir on a compassionate basis. Rapid...

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Bibliographic Details
Published in:Transplant infectious disease 2016-06, Vol.18 (3), p.442-445
Main Authors: Llaneras, J., Castells, L., Santos, B., Crespo, M., Puig, T., Esteban, J.I., Esteban, R.
Format: Article
Language:English
Subjects:
Antiretroviral drugs
daclatasvir
Hepatitis
hepatitis C virus
HIV
Human immunodeficiency virus
Liver
sofosbuvir
transplant
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Summary:We present a human immunodeficiency virus‐infected patient with severe decompensated hepatitis C virus‐related cirrhosis awaiting liver transplantation (LT) who received a 24‐week course of interferon/ribavirin‐free antiviral treatment with sofosbuvir and daclatasvir on a compassionate basis. Rapid viral suppression was associated with progressive improvement of his liver function tests. The patient achieved a sustained virological response and concomitant clinical improvement, which prompted removal from the LT list 12 weeks after the end of treatment.
ISSN:1398-2273
1399-3062
DOI:10.1111/tid.12538