Peroxisome proliferator-activated receptor-[gamma] is critical to cardiac fibrosis

Peroxisome proliferator-activated receptor-[gamma] (PPAR[gamma]) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily, which plays a central role in regulating lipid and glucose metabolism. However, accumulating evidence demonstrates that PPAR[gamma] agonists have...

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Bibliographic Details
Published in:PPAR research 2016-01, Vol.2016
Main Authors: Liu, Huang-Jun, Liao, Hai-Han, Yang, Zheng, Tang, Qi-Zhu
Format: Article
Language:English
Subjects:
Cardiology
Cardiomyopathy
Cell receptors
Clinical medicine
Deoxyribonucleic acid
Development and progression
Diabetes
DNA
Extracellular matrix
Fibroblasts
Fibrosis
Fractures
Gene expression
Growth factors
Health aspects
Heart attacks
Heart failure
Insulin
Ischemia
Kinases
Ligands
Metabolism
Mortality
Peroxisomes
Phosphorylation
Proteins
Rodents
Transcription factors
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Summary:Peroxisome proliferator-activated receptor-[gamma] (PPAR[gamma]) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily, which plays a central role in regulating lipid and glucose metabolism. However, accumulating evidence demonstrates that PPAR[gamma] agonists have potential to reduce inflammation, influence the balance of immune cells, suppress oxidative stress, and improve endothelial function, which are all involved in the cellular and molecular mechanisms of cardiac fibrosis. Thus, in this review we discuss the role of PPAR[gamma] in various cardiovascular conditions associated with cardiac fibrosis, including diabetes mellitus, hypertension, myocardial infarction, heart failure, ischemia/reperfusion injury, atrial fibrillation, and several other cardiovascular disease (CVD) conditions, and summarize the developmental status of PPAR[gamma] agonists for the clinical management of CVD.
ISSN:1687-4757
1687-4765
DOI:10.1155/2016/2198645