Neovascularization: Upregulating Hif-1[alpha] by Hydrogel Nanofibrous Scaffolds for Rapidly Recruiting Angiogenesis Relative Cells in Diabetic Wound

On page 907 Y. Liu, W. Cui, H. A. Santos, L. Deng and co-workers describe a novel water soluble desferrioxamine-loaded hydrogel nanofibrous scaffold designed to rapidly recruit angiogenesis relative cells. The scaffold promotes the healing process of diabetic wounds through up-regulating Hif-1[alpha...

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Bibliographic Details
Published in:Advanced healthcare materials 2016-04, Vol.5 (8), p.865
Main Authors: Chen, Hao, Jia, Peng, Kang, Hui, Zhang, Hongbo, Liu, Yi, Yang, Peilang, Yan, Yufei, Zuo, Guilai, Guo, Lei, Jiang, Min, Qi, Jin, Liu, Yuanyuan, Cui, Wenguo, Santos, Hélder A, Deng, Lianfu
Format: Article
Language:English
Subjects:
Angiogenesis
Diabetes
Hydrogels
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Summary:On page 907 Y. Liu, W. Cui, H. A. Santos, L. Deng and co-workers describe a novel water soluble desferrioxamine-loaded hydrogel nanofibrous scaffold designed to rapidly recruit angiogenesis relative cells. The scaffold promotes the healing process of diabetic wounds through up-regulating Hif-1[alpha] and its downstream genes. Furthermore, the degradation rate of the scaffold is effectively corresponding with the closing rate of the wound, leaving enough space for new epidermis formation.
ISSN:2192-2640
2192-2659
DOI:10.1002/adhm.201670037